Thus, ample evidence exists that genetic alterations affecting CK5/14-expressing cells, presumably a progenitor population, can give rise to IDC that contain cells with characteristics of both the luminal and myoepithelial lineages.
Unlike group A markers, these markers are not generally accepted as markers of clinical relevance by themselves (risk factors), but there is ample evidence from relevant subpopulations that (alterations in) these markers are associated with (alterations in) clinical outcomes, and this is supported by a plausible mechanism of action.
Despite ample means, enough to make sensitive alterations, instead, sometimes occupants have marred this landmark's gracious loveliness with inappropriate single-light 'picture windows' or unsightly openings for air conditioners.
There is ample electrophysiological and pharmacobehavioral evidence that alterations in serotonergic neurotransmission or differential serotonin receptor (5-HTR) activation in the amygdala impact anxiety-like behavior in rodents (Holmes 2008; Lowry et al. 2005).
Ample evidence has shown that the metabolic alterations are critical for the growth, proliferation and survival of tumor cells.
As far as CC is concerned, we can highlight the ample number of genes affected by epigenetic alterations at the level of gene methylation, histone modification, and miRNA action.
DNA damage response pathways are frequently mutated in individuals with inherited forms of cancer predisposition, and there is ample evidence that these changes accelerate the accumulation of genetic alterations that drive tumour-cell development.
Despite nonspecific pathophysiological mechanisms, there is ample evidence that the frequency contributions to HRV are altered in illness states, and that the degree of alteration correlates with illness severity.
There are thus ample opportunities for mutations that spread by neutral genetic drift to cause subtle alterations in a P450's promiscuous activities.
Furthermore, in order to identify prognostic alterations, the analysis of large numbers of well documented tumour samples with ample and accurate clinical follow-up data is required.
Although wettability alteration has been considered as the dominant mechanism, there is an ample space in this area needs to be explored more.
