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Overall, these results demonstrate the methamphetamine metabolite amphetamine does not contribute to methamphetamine's abuse-related subjective effects.
It makes you look up like that sometimes [demonstrates eyes rolling]." When asked what medication ought to do for him he said: "Give you something like amphetamine does for me, that's why I found the drug to cure me and to help me: amphetamine.
Amphetamine does increase levels of 5-HT as well as dopamine and noradrenaline (Balcioglu, Zhang, & Tarazi, 2003; Kuczenski & Segal, 1989, 1995; Kuczenski, Segal, Leith, & Applegate, 1987), therefore the therapeutic benefit derived from administration of amphetamine in ADHD may result in part from activation of the serotonergic system.
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The antipsychotic, haloperidol, and the psychostimulant, amphetamine, did not produce any anxiolytic-like effects (1 10 mg/kg s.c).
The non preexposed groups treated with amphetamine were not different from the non preexposed placebo group, indicating that amphetamine did not affect conditioning.
On the other hand, during male-female sexual interactions, amphetamine did not increase USVs at lower doses (0.2 and 0.5 mg/kg) (p>0.05), but suppressed USVs at higher doses (2.0 and 6.0 mg/kg) in males (Figure 8A).
This conclusion is also consistent with our preliminary data that intermittent intravenous administration of amphetamine did not increase lever pressing rewarded by visual signals (Suto, Shin & Ikemoto, unpublished observation).
In addition, co-administration of the mixed dopamine antagonist cis-z-flupenthixol with amphetamine did not alter the ability of the psychostimulant to decrease impulsive choice in sham-operated rats, but did block these effects of amphetamine in ICV 5,7-DHT lesioned animals.
On the basis of these findings, we infer that relief of perseveration by d-amphetamine does not require functional NK1R.
Reasons for these disparate findings are not known, but d-amphetamine does have beneficial effects in other measures of impulsivity in rodents (e.g., 'delay-discounting': [61]).
Studies conducted over the last 40 years suggest that low doses of amphetamines do not affect alertness, reaction time or decision-making ability in well-rested people.
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