With an accurate and detailed mathematical model of mammalian circadian clock, we studied how dosing amount, dosing timing, and day length affect the chronic dosing-induced phase delay.
The occurrence and magnitude of a stable phase delay depend on dosing amount, dosing timing, and day lengths.
We have shown that the interaction of two zeitgebers, light and dose of PF-670462 can lead to complex behavioral patterns, which depend on dosing amount, dosing timing, and day length.
The technique of perfluorocarbon administration and the amount dosed may need to be altered.
However, since the amount of OA in the diet was lower than the amount dosed by gavage (see below), some genes were expected to be regulated.
Five grams of the concentrated extracts were suspended in distilled water and measured amounts (dose) administered to the experimental animals with respect to their body weight.
Pharsight's "computer-assisted trial design" system models and simulates clinical trials to determine the optimal number of patients, dose amounts, and dosing frequency, all of which have for years mostly been determined through time-consuming and costly trial and error.
The observed maximum concentration (Cmax) after each dose and 28 days after each dose (C28) increased by small amounts from dose 1 through dose 2 to dose 3 at all dose levels.
The prescription database records the amount, dose and date for each reimbursed purchase.
The food matrix containing the food allergen can affect the amount (dose) of allergen available for digestion.
