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The patch formulation was optimized by investigating the effects of the drug loading capacity, the type, and amount of permeation enhancer on the adhesive properties and skin permeation.
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When the amount of permeated air became constant, the amount of air permeation was measured by the water substitution method (Fig. 1).
An integrative evaluation method suggested that the barrier performance can be consistently defined from total amount of water permeation.
The transfersomes and ethosomes provided a significantly higher amount of cumulative permeation, steady state flux, permeability coefficient, and residual drug into skin compared to the conventional liposomes, conventional gel, or hydroethanolic solution.
In particular, the effect of the permeation ratio (amount of gas permeated through the membrane relative to the amount fed) and the installed membrane area on the hydrodynamics was investigated.
The amount of tritium permeated was compared with permeation rates predicted by numerical simulation codes (TMAP4 and TPERM).
The permeation profiles were constructed by plotting the cumulative amount of drug permeated versus time.
The amount of sorption and permeation flux of chloroform, toluene, methanol, and n-butanol were calculated using this method and compared with experimental data.
Furthermore, in a goat intestinal permeation study, formulation F4 gave significantly higher mean cumulative amount of drug permeated at 48 h than Glinate™ 60 and control and, in a pharmacodynamic study, produced a significantly greater reduction in blood glucose.
The permeation profiles of NTG through goat intestine were constructed by plotting the total cumulative amount of drug permeated per unit surface area (d M/ A µg/cm) versus time t (h).
A goat intestinal permeation study revealed that the provesicular formulation (F4) with an SP CH ratio of 5 5 gave higher cumulative amount of drug permeated at 48 h compared to Glinate™ 60 and control.
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