We did not pro-rate the PICs by the sequence length in these comparisons (lengths of each region are variable, particularly for non-coding regions), since the most important outcome from a barcoding perspective is the amount of information retrieved for a region, not the amount of information per nucleotide sequenced.
In addition, activity is modulated by the amount of information retrieved, so that when a subject can recall a larger amount of information about a remembered event, activity in lateral parietal cortex is increased (Vilberg and Rugg 2007).
A graded pattern of responses is observed in this region, as a function of the amount of contextual information retrieved (Henson, Rugg, et al. 1999; Konishi et al. 2000; McDermott et al. 2000).
However, the blocked design of this study did not allow isolation of individual encoding trials based on the quality or amount of information subsequently retrieved.
To achieve this, we used a novel paradigm to create, for the first time, experimental conditions that differentially loaded onto the amount of information being retrieved as opposed to executive demands.
This highlights the limits of a fully automated procedure, but still, a significant amount of information can be retrieved.
Since genomic deletions and hypermethylation appear to be the main mechanism of FHIT and WWOX inactivation [ 6, 9, 30, 31] a significant amount of information can be retrieved from the retrospective evaluation of archived paraffin embedded specimens.
To provide further insight into the kinds of mnemonic characteristics that might enable reality monitoring of action memories, immediately after leaving the scanner, participants rated their recollection of each studied object according to a number of qualitative factors that included the amounts of internally and externally generated information retrieved.
In the investigated case studies the precision of the estimated parameters could be improved by up to a factor of ten, confirming the usefulness of this approach to maximize the amount of information that can be retrieved from a fixed number of samples.
The more relevant the person is to oneself, the wider the range of stored information associated with that person and, consequently, the greater the amount of information that is automatically retrieved and integrated when presented with appropriate stimuli [8].
It is important to maximize the amount of information that can be retrieved from a single sample.
