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To further investigate the physiological role of CSPG4, we examined the effect of NG2 knockout in response to systemic TcdB challenge, as the toxin is disseminated into systemic circulation in severe infection and the disease severity can be precisely controlled by the amount of challenged toxin.
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There's a significant amount of challenging, fun and hard work to do, and we want to engage in that as a broader community," he says.
And there's no amount of challenging expectations before the trip that would have wholly grounded those unrealistic hopes.
Give your cat a sufficient amount of "challenging play.
The levels should be engaging and just the right amount of challenging.
He used nearly the maximum amount of challenges, and was 2 for 12 against the Hawk-Eye instant replay.
"Brexit has presented a huge amount of challenges for the Irish government in terms of the trading relationship with Britain, both to the UK and between Northern Ireland and Ireland.
Even the smoothest birth is testing and most women go through an untold amount of challenges to their self-esteem, beliefs and ego.
Think of it like training for a race: a runner needs just the right amount of challenge to improve and get stronger.
When he and Addington were in high school, Napolitano said, the Vietnam War was in its final stages, and "there was a certain amount of 'Challenge authority' and alcohol and drugs, but they weren't issues in our group".
"I know how tough and hard it can be, and how so many families can get to the end of their tether and just not know how they are going to go on caring for someone they absolutely love and feel a great joy from, as well as a huge amount of challenge in their lives.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com