Arthritis was induced by intraperitoneal injection of arthritogenic (K/BxN) or control (BxN) serum on day 0. The amount administered was 150 μl for mice used in functional tests, as debilitating joint dysfunction produces gait abnormalities and limits functional nociception measurements.
For the purpose of the present study, we calculated the caloric intake from the amount of calories provided by enteral nutrition, parenteral nutrition and non-nutritional solutions (i.e. total glucose amount administered intravenously).
aTotal amount administered during shock.
The sum of the Animal Defined Daily Dose (ADD), which quantifies the total amount of antimicrobials administered for each period and for the total risk period were 11, 96, 3, 3, 3 and 54 for each of the drug classes, respectively.
Thyroid stunning is a debated phenomenon where a low amount of radioiodine administered for treatment planning results in a lower thyroid uptake of administered radioiodine at the subsequent treatment [30].
Such normal organ uptake may be overcome to some extent by optimizing the protein amount of antibody administered for therapy, helping to protect normal tissues and potentially preserve immune cells by saturating non-tumor PD-L1 sites.
The most obvious one is an inadequate amount of insulin administered for the induction of an immunomodulatory response.
Similar results were observed using the amount of fluid administered for intravascular volume expansion during the first 12 hours of the study.
At equitoxic doses, the amount of drug administered for N-l-leucyl-doxorubicin and vinblastine-isoleucinate was respectively 3-fold and 2-fold higher than the doses of the parent compound.
The daily amount of fluids administered for intravascular volume expansion was higher in the control than in the preload dependence group (917 (639 to 1,511) versus 383 (211 to 604) mL, P = 0.01), and the same held true for red cell transfusions (178 (82 to 304) versus 103 (0 to 183) mL, P = 0.04).
