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The authors confirm inter-tumour heterogeneity amongst distinct metastases of a single patient and identify three independent BRAF amplification events, a novel aberrant form of BRAFV600E that contains an unknown N-terminus, and a novel MEK1 mutation, which was detected in two out of five metastases.
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There is a subtle caveat with respect to the concept of just how "informative" a sequence is: because sequence conservation can stem from two extremes (i.e. conservation amongst phylogenetically distinct sequences or merely redundancy due to phylogenetic/sampling bias), the sensitivity tools we present here are not completely adequate to decide whether an initial dataset is optimized.
SNVMix2's design would be able to leverage the read's quality amongst the distinct coordinates and still use the information it conveys to predict SNVs.
The response to dovitinib was distinct amongst patients indicating differential drug effects between patients.
Hearing, however, is distinct amongst the senses in having extensive pre-thalamic processing in the brainstem.
Amongst these immunophenotypically distinct subpopulations, the CD19+CD138− cells had a superior colony forming capacity compared to the CD138+ population [ 75].
Amongst these three distinct study groups, health professionals generally express a feeling of responsibility towards at-risk relatives but identify difficulties in acting upon this responsibility.
The similarity in the response to grazing intensity amongst two ecologically distinct species, a rodent and an insectivore, points to a common environmental parameter as driver of the population dynamics.
Employing a systems biology approach, we have identified for the first time the transcriptional profiles and corresponding biological processes that characterize the scope of ARI symptoms amongst four clinically distinct groups.
This has enabled us to identify a number of distinct patterns amongst participants' accounts, as outlined in Sects.
Studies suggest that certain lineages preferentially cause active tuberculosis amongst human populations with distinct genetic ancestry [6], [7].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com