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Among these trials nASSwS and nASwR were clearly separated from nAS and nASS.
To analyze the randomized clinical trials in exudative age-related macular degeneration (AMD) to reveal apparent differences in the behavior of untreated control eyes among these trials.
It would be attributable to some common characteristics among these trials, such as relatively uniformed chemotherapeutic regimens (cisplatin-based ones) and larger number of the registered patients.
Comparing outcomes among these trials is extremely difficult.
Methodological quality in general among these trials was good.
There was considerable heterogeneity among these trials (I=55%, χ=8.89; P=0.06).
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Study design differences may account for the broad variability seen among these trial outcomes.
Intermingled among these 20 trials were five additional trials of elemental discrimination (cross vs. circle).
Similarly, APOE ε4 carrier status differed among regions in these trials, and this may bear on the number of non-AD patients entering trials that do not utilize AD biomarkers as entry criteria.
There were no significant differences in the groups among these three trials (Friedman test, p > 0.05).
Among these 22 trials are two of the largest and highest profile clinical trials in the US: the National Lung Screening Trial NLSTT), evaluating whether imaging screening reduces lung cancer-specific mortality; and the Digital Mammographic Imaging Screening Trial (DMIST), which compares the effectiveness of conventional and digital mammography.
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