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Exact(8)
Knowledge of the relationships among dose, drug concentration in blood, and clinical response is important for the safe and effective use of drugs in individual patients.
This study was undertaken to clarify the relationships among dose, plasma concentration time course, therapeutic efficacy, electrocardiographic effects, and toxicity of amiodarone during the initiation and maintenance of oral therapy.
Antibody response rates to Env antigens were most frequent, ranging from 75% to 95% of participants across clades and doses, with geometric mean titer (GMT) ranging between 102 and 187 among dose or clade groups.
The incidence of TEAEs varied among dose groups.
Survival did not differ among dose groups, and the survival-adjusted lifetime tumor rates were 44%, 74 %, 74, and 73%, respectively.
For the comparison of clinical response among dose groups (3, 6 and 10 mg/kg), logistic regression analysis was performed using the clinical responses at the time of randomisation (week 10) as a covariate.
Similar(52)
In contrast to the timing of estrus, the timing of the LH surge (after start of infusion) was not different among doses (P = 0.88).
However, this was considered too high, and the difference among doses in the range of 0.20 0.50 mmol Gd/kg was small.
Variability was observed among doses administered in the public and private sector by state.
Typically, dose information is simply not available, and the variability among doses consumed by individuals is almost never known.
Twice-daily and once-daily dosing and switching among PPIs and among doses could also be driven by insurance-related factors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com