Samples from patients with AML were used as negative controls.
cDNAs and genes encoding venom PLA2s were amplified from the venomous glands of Vipera snakes and probes specific of european viper venom PLA2s (AmI2, AmI2, vasA, vasB, AtxA/C and AtxB, AmL) were used for PLA2 profiling.
In light of past decision by the FDA, the RCT for decitabine (DACO-016) in the treatment of AML is used as an illustrative example.
Leukaemic cells from ten patients with acute myelocytic leukaemia (AML) were used, five with undetectable mdr1 gene expression and five with mdr1 mRNA levels ranging from 1.0 to 3.8 mRNA mRNA transcripts per cell.
In previous studies of multikinase inhibitors in AML, Western blotting was used to determine the pharmacodynamic effects of sunitinib.
Well-characterized mouse models of AML (AML) have been used to explore the molecular basis for the stem cell-like behavior of sub-populations of leukemia cells [ 48].
In a recent report, SCNP analysis of a separate cohort of AML samples taken at diagnosis was used to describe correlations between an expanded panel of intracellular signaling pathways with clinical response to induction therapy [28].
In this study, deep sequencing was used to distinguish AMLs and CMLs by comparing the miRNomes between the AML lines HL-60 and THP-1 and the CML line K562 and to elucidate the differences in miRNA expression at various differentiation stages.
Surface marker CD44 was used as a target in AML therapy [39].
The checkerboard procedure [ 10] was used to determine the combined effects of AML and imipenem.
MS-HRM was used to assess CDKN2B methylation in acute myeloid leukaemia (AML) samples.
