Sentence examples for aml activity from inspiring English sources

The current study was designed to explore the role of circulating EVs as potential biomarkers of AML activity and predictors of thrombogenicity in patients with this malignancy.

This raises the possibility that the AML quintuple insertion homozygote lines do not represent total disruption of AML activity.

Viewed in this light, the early flowering phenotype of AML insertion homozygotes may arise not from the total disruption of AML activity but from the accumulation of AML proteins which, due to the truncations in their N-termini caused by the insertions, are no longer bound by AtRaptor1B, no longer phosphorylated by AtTOR, or no longer able to activate transcription of floral repressors.

Therefore, JMJD3 exerts a potential anti-AML activity in a subtype and oncogenic fusion protein-dependent manner.

Based on our recent discovery of a new scaffold class by in vitro protein-based optimization, it was surprisingly found that YH239-EE (the ethyl ester prodrug of YH239) exhibits potent anti-AML activity in different cell lines and patient samples.

In this contribution, a comprehensive study including discovery by computational chemistry, chemical optimization, biochemical, NMR, and X-ray crystallography and cellular characterization in cell lines and patient derived samples is presented to better understand the basis of its anti-AML activity.

We conclude that in AML, calpain activity is very high and heterogeneity of activity is apparent.

These data, together with previous observations that the HIFs directly mediate glioma, lymphoma and AML TIC activity [ 15, 16], suggest that attenuation of HIF activity may effectively eradicate TICs in a variety of cancers, leading to improved therapeutic response and overall survival.

In conclusion, our results have demonstrated that serum concentrations of all TNF superfamily could constitute a useful biomarker of AML disease activity and progression.

Combined bezafibrate (BEZ) and medroxyprogesterone acetate (MPA) exert unexpected antileukaemic activities against acute myeloid leukaemia (AML) and these activities are associated with the generation of reactive oxygen species (ROS) within the tumor cells.

AML improved the activity of imipenem against A. baumannii isolates in vitro, but it did not work by inhibiting MBL.