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Standard mathematical testing, repeated revisiting of the literature, and numerous rounds of amendments and refinements resulted in models that are stable and rather insensitive to perturbations in inputs or parameter values.
Although the basic structure of the WHO clinical case definition has been fixed since 1990, there have been amendments and refinements that are reflected by subsequent WHO documents.
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5 Other significant challenges in many countries are systemic infrastructure issues such as contract and budget negotiation and approval, protocol amendment and refinement, and review and approval of consent forms.
Mirkin told Richmond that the script would require the equivalent of ten rewrites: "At every step, there are amendments and additions and refinements".
Regarding the latter, the model is found to be in need of amendment and further refinement to ensure its clarity and logical coherence.
Small glitches and refinements continued into spring.
How did she handle the leisurely pace and refinements of the show itself?
No doubt, there are many permutations and refinements on this set of suggestive ideas.
Then notes were given, directions changed (sometimes radically) and refinements made.
All amendments and exclusions are listed in Supplementary Table 3.
Amendments and annual reports underwent ethics committee review.
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