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The application was then submitted to the NHS Research Ethics Fulham Committeee) for proportionate review, where favourable opinion subject to minor amendments was issued (reference no 14/LO/0169).
Consequently, an amendment to the study protocol was issued before unblinding, defining a secondary efficacy analysis of the primary endpoint that is, analysis of a binary endpoint (progression vs non-progression at 3 years) derived from the continuous JSN.
No fewer than 25 such amendments have been issued over the last 18 months, airline industry executives said.
When James Monroe exercised his first and only veto, rejecting a bill imposing tolls on the Cumberland Road because he believed a constitutional amendment was required, he issued a 25,000-word explanation along with it.
Driving the argument behind the amendment was the issue of sexual assault in the military.
Interestingly, the original Blaine Amendment was not a state issue but a national issue.
This was rejected, but an amendment was made allowing nations to issue their preferred orders in their own territorial waters.
Bricker's amendment was raised as an issue in his 1952 re-election campaign.
"The recent General Election in Ireland showed that dismantling the 8th Amendment was not a big issue for voters at all," Sherlock said.
"Gun rights and the Second Amendment are swing issues for voters in western Pennsylvania," said John Lee, director of legislative affairs for the Pennsylvania Rifle and Pistol Association, the N.R.A.'s state affiliate.
The 1st Amendment is one issue.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com