Our preliminary biological evaluation indicated that the amide moiety of ceramide is amenable to bioisosteric substitution with the triazole moiety.
All patients, regardless of the maturity found in the regenerated bone after the distraction period, are amenable to plate substitution; where the maturity of the bone regenerate is in question, or in situations in which a presumption of poor prognosis of consolidation at the docking site level is of poor quality, the procedure is performed with bone grafting.
Heteroarenes containing a nitrogen are more electron deficient than the corresponding aromatic hydrocarbon and, thus, are amenable to direct substitution for F-fluoride without an additional activating group.
This reaction proceeded in higher 66% yield, presumably because the chloro-substituted pyridine is less amenable to competing nucleophilic substitution than its fluoro-substituted counterpart.
Considering the longer half-life of fluorine-18 (109.77 min vs 20.33 min for carbon-11), L-2b was also interesting as the pyridine ring made it amenable to nucleophilic-aromatic substitution with fluorine-18.
32d, [ 37] Pyrene is usually functionalised at the 1-, 3-, 6-or 8-positions where the maximum contributions of the HOMO lie, making it most amenable to electrophilic aromatic substitution.
Although HDAC8 mutants H180R and G304R were not amenable to crystallization, the structural consequences of these substitutions were evaluated in MD simulations.
On the other hand, H-like structures are more condensed because the 3, 5 positions on the benzyl ring are occupied by hydrogen which produces lesser stearic effects as compared to methoxy groups, making it amenable to further carbon-carbon bond formation via nucleophilic substitution reactions.
She's amenable to anything.
Heroin addiction is particularly amenable to treatment.
