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Are there structural features that make a fold amenable to functional innovation (innovability)?
Here, we show that this proton sensor can be modified to engineer a constitutively open form of KcsA, amenable to functional, spectroscopic and structural analyses.
Due to portability and wear-ability advantages, HD-DOT has the potential to be used in populations that are not amenable to functional magnetic resonance imaging (fMRI), such as hospitalized patients and young children.
Our simulation approach also enables researchers a priori to design experiments and data-collection protocols that are amenable to functional network inference.
Moreover, we demonstrate that the system is amenable to functional assays.
Bees have rich and quantifiable learning and memory repertoires [25], [26], are amenable to functional genomic research, and provide the best-studied social invertebrate system to date [32], [43].
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Electrospun fibrous scaffolds can be prepared with high degree of control over their structure creating highly porous meshes of ultrafine fibers that resemble the extracellular matrix topography, and are amenable to various functional modifications targeted towards enhancing stem cell survival and proliferation, directing specific stem cell fates, or promoting tissue organization.
Coding variants that are predicted to have severe functional consequences may be hypothesized to confer larger phenotypic effects, have higher translational potential and may be more amenable to designing downstream functional experiments.
Furthermore, we demonstrate that this 2G12 (Fab)2 display system is amenable to selection of functional clones using a mock selection.
Advances in glioma modeling in the mouse have made the disease amenable to in vivo functional and molecular studies [3].
Our findings indicate that EMT does not induce multipotency in the dedifferentiated beta cells, suggesting that they retain a restricted differentiation potential and may be amenable to redifferentiation into functional beta cells.
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