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Although human β-cardiac myosin would be clearly the isoform of choice for our studies, expression levels of human β-cardiac myosin heavy chain [19] and of rat α-cardiac myosin [13] have been very low, and thus are not amenable to extensive biochemical and structural studies.
Importantly, the N moiety of adenosine receptor agonists is known to be amenable to extensive structural variation while retaining receptor interactions.
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Molecular diagnosis of Norovirus infection can be a complex multistep process, which requires significant user intervention and expertise, and is not amenable to automation without extensive validation and optimization.
However, the devices utilized in current mouse models of implant-associated bone infection have been limited to intramedullary or trans-cortical pins, which are not amenable to treatments involving extensive debridement of a full-thickness bone loss and placement of a segmental antibiotic spacer.
The authors did test two rather acute and rather similar perturbations without success, though the zebrafish would seem to be amenable to much more extensive and stringent challenge.
As microbial hosts, Escherichia coli and Saccharomyces cerevisiae have often been employed, since they, specifically the former, are fully amenable to genetic manipulations with extensive molecular resources.
The analysis suggests that a wide variety of reaction rate (kinetic) processes and models, in chemistry, biology/ecology, unit operations and contaminant transport, are amenable to analysis by Tsallis' non-extensive statistical mechanics.
Autonomic dysreflexia occurs after spinal cord injury at or above the sixth thoracic spinal segment, because injury at this level leaves the sympathetic control of the extensive abdominal circulation amenable to unrestrained spinal reflexes.
The use of spatial methods that discriminate within smaller units will generally be more effective in isolating the exposure of concern from other geographically based health influences because confounding may be less extensive and more amenable to analytic control.
Although curative resection or liver transplant is widely adopted as treatment for HCC [ 5], a majority of HCC patients are not amenable to surgical resection due to the extensive intrahepatic tumor burden or limited donor resources.
In terms of tumour control, stage C (grossly displaced third ventricle) and D (intracranial parasellar extension) are potentially amenable to total removal with our technique; stage E (extradural parasellar extension) lesions may require a more extensive extradural approach.
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