The described pellet formulation is amenable to oral dosing in small animal studies in order to assess in vivo efficacy of the whey-derived ghrelinergic hydrolysate.
However, recent studies including those from our lab indicate that liposomal as well as nanoformulations of curcumin are more water soluble and bioavailable, facilitating the intravenous administration of curcumin, rendering it amenable to systemic dosing.
The half-life of dapagliflozin (12.5 h) and the corresponding sustained inhibition of urinary glucose reabsorption over 24-h after dose at the proposed clinical dose (10 mg) is amenable to once-daily dosing.
13, 14 Liraglutide was approved in 2010 and has a longer half-life amenable to once-daily dosing, with greatest effect on fasting plasma glucose (FPG).
The pharmacokinetic profile of liraglutide is amenable to once-daily dosing, thus creating a potential advantage when compared with twice-daily exenatide.
The increasing database of biomarker information in CIT may provide the foundation for the next generation of CIT models, including those that are more amenable to questions of optimal dosing duration.
Among these, parameters of drug exposure are most amenable to regular monitoring, and may potentially provide insight towards dose optimisation.
Also it has been shown that a single lesion, i.e. minimal metastatic disease called "stage IV oligometastatic disease", amenable to local therapy (surgery and/or radiation) followed by high dose chemotherapy is considered another different favourable condition [ 39, 40].
We hypothesize that this deleterious inflammatory response contributing to PVR may be amenable to early modulation by aggressive anti-inflammatory therapy, including higher doses of oral or even periocular costicosteroids.
These end points were selected based on the presence of a significant dose-related trend, on data that was amenable to modeling, and on the relevance to changes in lung function in humans.
