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Imaging biomarkers have provided useful pharmacodynamic information (O'Connor et al, 2009), but these are expensive, restricted to clinical trial sites with specialised expertise and less amenable to comprehensive serial sampling than blood-based analyses.
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The methodology herein described for Literature Lab highlights the biomedical literature as a content-rich resource amenable to automated, comprehensive interrogation.
It is only then that a comprehensive representation amenable to mathematical modeling really becomes available[7].
Such reduced models are useful to test alternative biological hypotheses and can be amenable to detailed analysis using bifurcation theory and comprehensive sensitivity analysis [ 74].
Relevant; Comprehensive (in relation to the purpose of the study); Comprehensible to the respondent; Amenable to analysis.
Enquiries into burden should be: Relevant; Comprehensive (in relation to the purpose of the study); Comprehensible to the respondent; Amenable to analysis.
The current model is comprehensive, but we used a modeling approach that is very amenable to adding further details and making modifications as subsequent experimental data and new hypotheses emerge.
Although heterogeneity of tumor cell populations has been widely studied, there is no general approach that would provide a comprehensive description of intrinsic heterogeneity of tumors and would be amenable to qualitative and quantitative mathematical analysis.
Compared to other vertebrate models, zebrafish larvae are more amenable to in vivo imaging experiments because of their transparency and external development, allowing a more comprehensive description of cardiomyocyte fate.
Still missing is a comprehensive analysis of the expression of putative CSC markers in very large groups of patients, amenable to detailed statistical analysis.
Since the publication of the first comprehensive linkage map for the laboratory mouse, the architecture of recombination as a basic biological process has become amenable to investigation in mammalian model organisms.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com