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The inability of EWS/ATF1 to activate the Mitf-M promoter in melanocytes, under conditions in which the promoter is amenable to activation by cAMP, supports this idea.
How to avoid activation or repression of unwanted targets to initiate lineage-specific programs, and how to activate or shut down certain pathways to obtain temporal gene expression signatures amenable to unique cell fate.
Five lactam chemotypes amenable by the Castagnoli-Cushman reaction of imines and cyclic anhydrides have been investigated for their ability to activate p53 tumor suppressing transcription factor thus induce apoptosis in p53+ cancer cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com