Strategically, by committing the necessary resources to the development of synthetic sequences and scaffolds that were most amenable for late stage structural diversification, even as the focus of the SAR campaign moved from one end of the molecule to another, highly potent renin inhibitors could be rapidly identified and profiled.
Earlier detection can benefit patient survival and treatment options; however progress is still needed in developing therapeutic strategies amenable to early stage disease.
Colorectal cancer is one of the most amenable to extracting stage from pathology reports, with the main limitation being a lack of information about metastasis [ 42].
In spite of regular screening and surveillance of patients at high risk for development of HCC, only about 30%60%% of cases can be diagnosed at a stage amenable to curative treatment options.
This model postulates that change is a process that proceeds through specific stages, each of which has key characteristics – characteristics that are amenable to targeted, stage-specific or matched interventions.
The structural design of candidate radiotracers must be amenable to late-stage diversification and facile radiolabeling, because many iterations of a chemical series may be needed before a suitable tracer is identified.
Eligible participants were with biopsy confirmed single primary site colorectal adenocarcinoma; aged 21 90 years; with all stages amenable to surgical treatment and not requiring neoadjuvant treatment; with planned curative resection; and with written, informed consent.
In general, regenerative strategies, such as cell, gene and protein therapy, are more amenable to early-stage degeneration that is localized to the NP (Fig. 2B) (Leung et al., 2006; Masuda, 2008; Sakai, 2008; Sobajima et al., 2004; Wallach et al., 2003).
This stage is amenable to determining the uniformity of expression owing to its simple morphology.
Vulvar squamous cell carcinoma is usually diagnosed in a stage still amenable to potentially curative treatments, including surgery and/or radiation therapy with or without chemotherapy.
