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Our results demonstrate that the novel lipo-amino acid is highly flexible to synthesize and carry out the extensive structure activity relationship (SAR) on lipo-antimicrobial peptidomimetics and represents a unique amenable platform for modifying parameters important for antimicrobial activity.
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To successfully apply the genetically amenable zebrafish platform to the study of complex immune-mediated disease, a broader understanding of zebrafish immunogenetics is required.
The tolyl triazole amides provided a potent platform amenable to optimization.
The nanovector prototype described here can be a valuable platform amenable to modification and improvement with the objective of designing a nanostructure adequate to enter the preclinical pipeline as a new antimalarial therapy.
Murine ES cells were first reported in 1981 [ 5] and represented an amenable and convenient platform to study developmental pathways and the sustenance of pluripotency.
Finally, the flexibility in the size and number of sample cavities per device makes the platform amenable to match the dynamic range and resolution requirements for the gene of interest.
The value of spheroid cultures is increasing quickly due to novel microfabricated platforms amenable to high-throughput screening (HTS) and advances in cell culture.
We conclude by identifying future challenges and opportunities in this field, including the development of microenvironmental platforms amenable to high-throughput discovery and screening.
With respect to cardio- and hepatotoxicology the establishment of reproducible and inexpensive differentiation protocols that are amenable to HTP platforms is still a challenge.
Don't expect a shippable solution to come out of Google's event next week, but expect to see that platform be amenable to third-party hardware solutions.
This platform is amenable to scaleup, and will expedite HBx production for structural and clinical studies, leading to the development of HBx-based therapy for liver cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com