Therefore, finding possible orthologs of Yfr1 in one of the cyanobacterial model species amenable for genetic manipulation would be desirable.
More importantly, they are amenable for genetic manipulation to incorporate and express ectopic genes, and for selecting subclones and transfected stable clones which retain their ability to differentiate.
Although the traditional method may be more technically rigorous, it is very labor-intensive and therefore expensive [ 22, 23] especially in B. fragilis species that is less amenable for genetic manipulation due to its Restriction/Modification system [ 24].
While aging has been being recognized as a strong disease modifier, this pathway was not fully amenable for therapeutic manipulation until the discovery of sirtuins (de Oliveira et al, 2010, 2012).
These steps are highly amenable for genetic manipulations to increase the oil content.
However, unlike A. balhimycina, A. orientalis is not amenable for genetic manipulations because of difficulties encountered in DNA transformation [ 17].
In the last decade, the moss Physcomitrella patens has emerged as a powerful plant model system, amenable for genetic manipulations not possible in any other plant.
In summary, there is a need for controlled experiments in laboratory and field settings for those stressors (e.g., toxicants, nutrients, turbidity) amenable to manipulation.
Deconstructing and detailing these mechanisms will allow for more targeted approaches and highlights how immune processes are amenable to manipulation by synthetic biomaterials.
Mice and rats are highly amenable to manipulation and are small enough to fit into hypoxic chambers for long periods of time (Yu and Hales, 2011).
