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Heretofore, the treatment for lung diseases like IPF has focused largely on the amelioration of potential inciting processes, such as inflammation.
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The authors' genetic rescue experiments provide a foundation for potential amelioration of pathogenesis in the animal model, and eventually in patients.
Treating OSA early on in patients with parenchymal lung disease may not only offer the potential of impacting the course of the underlying lung disease but also the potential for amelioration of the cough seen in these disorders [ 29].
Taken together, our results imply that PTEN depletion may protect motor neurons by inhibition of excitatory transmission that represents a therapeutic strategy of potential benefit for the amelioration of excitotoxicity in ALS and other neurodegenerative disorders.
Fenofibrate, a PPAR-α agonist increases levels of miR-301a/miR- 454, with potential for amelioration of pulmonary hypertension.
37 38 56 Our findings indicate that expanded insurance coverage has considerable potential for amelioration of disparities related to race and income in use of elective surgery at the national level in the US.
As ASK1 activation is also important for inflammatory cell migration and activation, inhibition leads to an amelioration of the inflammatory response, a potential contributor to adverse outcomes in some disease processes.
The transplantation of autogeneic mitochondria for the amelioration of myonecrosis offers a unique therapeutic potential.
Each of these has a specific rationale for potential use for amelioration of organophosphate-induced developmental neurotoxicity.
Model predictions showed that the drop in free IL-1β concentrations after binding to free canakinumab has a greater potential for the amelioration of patient symptoms as compared with the placebo effect (Emax 0.75 vs. 0.25).
Amelioration of cell death in a relevant iPSC-derived neural lineage could be a useful indicator of potential drug efficacy.
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