Sentence examples for amelioration of bone from inspiring English sources

However, it is also possible that significant amelioration of bone phenotypes may also be achieved using pharmacological strategies.

In mice, treatment with a neutralizing anti-RANKL monoclonal antibody in CIA resulted in amelioration of bone loss [ 86].

There is consequently significant interest in the identification of new bone anabolic agents for amelioration of bone disease.

In addition, chemotherapy treatment usually results in amelioration of bone marrow disease, so that the likelihood of considerable bone marrow involvement exceeding 25% is extremely low.

While some studies show no effect despite benefit on BMD [ 47], others did show an amelioration of bone turnover [ 48, 49].

The differential regulation of osteoclastogenesis by Notch2/Dll1 and Notch1/Jagged1 axes may be a novel target for amelioration of bone erosion in RA patients.

Furthermore, TGF-β is a multi-functional cytokine which suppresses normal hematopoiesis[42] and dendritic cell differentiation[43] but enhances angiogenesis[44] as well as osteoclastogenesis.[45] Therefore, the effect of TGF-β inhibition may extend beyond amelioration of destructive bone lesions and tumor growth and improve other MM-associated clinical features.

We further evaluated the amelioration of arthritic bone, and the joint structure was well conserved in the vaccinated mice compared with the positive control mice as demonstrated by microcomputer tomography (CT) scanning).

Then, other group further clarified that IL-27 directly acts on osteoclast precursor cells and suppresses RANKL-mediated osteoclastogenesis through STAT1-dependent inhibition of c-Fos, leading to amelioration of the inflammatory bone destruction.

Intra-articular injection of the T-cell specific PKC-theta inhibitor PIF on days 10 and 12 did not result in amelioration of arthritis nor reduced bone erosion.

Therefore we can argue that the amelioration of wound healing and bone fracture of reptiles observed here may be due to a proliferation of the germinativum stratum of the epidermis and of the embryonic mesoderm responsible for the formation of connective tissues, vascular tissues, sensory structures and osteodermis.