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In low concentrations (4%–10%), they are ubiquitous components of nonprescription creams and lotions that are promoted as being effective for ameliorating skin aging.
These experimental evidences prompted the use of EPO in improving impaired wound healing; as a matter of fact our group already demonstrated the efficacy of recombinant EPO in ameliorating skin repair during diabetes and burn injury [ 11, 12].
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In order to further test this hypothesis, we examined whether rhBMP-7 could ameliorate skin fibrosis induced by subcutaneous administration of bleomycin.
One recent open label study has suggested that TNF inhibition may ameliorate skin disease [51] and a case report has suggested some possible value for PAH [52].
However, dose reduction and/or dexamethasone prophylaxis appeared to ameliorate skin-related symptoms in most patients, facilitating repeat dosing.
It is well documented that verbascoside promotes skin repair and ameliorates skin inflammation [ 14].
Histological analysis of the skin of control, RBP-JK5 and RBP-JK5/G-CSF+/− mice showed the development of an AD-like disease in both mutant mice, implying that reduced G-CSF serum levels did not ameliorate the skin phenotype (Figure 6C), which is expected as TSLP serum levels are still elevated in the RBPJ-K5/G-CSF+/− mice (Figure 6D).
These effects might represent the main mechanisms by which RLX ameliorates the skin repair process.
Malarial infections ameliorated AD-like skin lesions in the NC/Nga mice.
Conversely, reduction in caspase-8 markedly ameliorated the skin phenotype but did not prevent splenomegaly or liver inflammation.
We have experimentally demonstrated for the first time that malarial infections ameliorated AD-like skin lesions in a mouse model of AD.
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