This generates scope for primary preventative interventions, ameliorating, not only classical modifiable risk factors such as; smoking, hypertension, diabetes mellitus and hyperlipidaemia but also non-traditional risk factors such as; functional iron deficiency, anaemia, insulin resistance and vitamin D deficiency [ 4- 6].
Additionally, inhibition of MBL and the lectin pathway in the latter settings might even "kill two birds with one stone" by ameliorating not only CIN but also tissue damage caused by the initial ischemic event and subsequent reperfusion via therapeutic revascularization.
It was a power, he argued in later work, that could ameliorate not only mental and physical problems but also societal ones.
Indeed many data have already allowed us to ameliorate not only our knowledge about cancer onset, but also about patients treatment.
Common therapeutic interventions, such as tricyclic (TCA) and selective serotonin reuptake inhibitor (SSRI) antidepressants, have been shown to ameliorate not only the psychological components of panic disorder but also the respiratory disturbances.
On the other hand, physical activity and aerobic exercise ameliorate not only the motor function but also swelling and stiffness of the joints in clinical practice.
Interestingly, tau ablation prevented or ameliorated not only epileptic activity and premature mortality in Scn1aRX/+ mice, but also their deficits in learning/memory, nest building, and other behaviors.
In the present study we sought to determine whether TLR9 stimulation by CpG ODNs can ameliorate not only Aβ related pathology but also tau related pathology, while concomitantly reducing oligomer levels in the 3xTg-AD mouse model.
Our study showed, however, that SB203580 could ameliorate not only lung inflammation but also excessive proteinase production, oxidative DNA damage, and apoptosis, indicating the further possibility of using p38 MAPK inhibitors as a new drug for the treatment of COPD.
45, 46 Our group has obtained interesting results showing how chitin nanofibrils can ameliorate not only the appearance of photoaged skin 47– 51 but also promote wound healing by reducing hypertrophic scar formation 52, 53.
Several studies in different animal models of RA clearly show that in vivo gene delivery to one diseased joint is highly effective in ameliorating disease not only in that joint, but in the contralateral joints as well [ 11- 13].
