They developed augmented conduction velocity and ameliorated blood flow of sciatic nerve.
Whereas the increases in MFI suggest that levosimendan ameliorated blood flow within the perfused vessels, the increase in PPV with a concomitant decrease in heterogeneity index indicates a recruitment of non-perfused vessels and hence a reduction of the diffusion distance between capillaries.
Administration of arginine within 20 min following ischemia ameliorated cerebral blood flow and reduced infarct volume [ 38, 39], whereas arginine resulted in a worse outcome when administered 12 h following middle cerebral artery occlusion (MACO) [ 40].
Stokes recognizes the cyclical nature of frequent decompensation in congestive heart failure, the relationship of clinical deterioration and reduced urine output, and the importance of reestablishing urinary flow to ameliorate dyspnea.
Oi and colleagues [ 17] showed in a porcine endotoxin shock model that a 7.5%saline/6%dextran-70dextran-70n improved cardiac output, portal and intestinal mucosal blood flow and ameliorated the intestinal-arterial pCO2 gradient compared to isotonic (0.9%) saline/6%dextran-70dextran-70
Furthermore, EH-201 (THSG) improved blood flow and ameliorated vascular senescence in spontaneously hypertensive rats (SHRs) (Han et al., 2012), without affecting blood pressure and body weight, after treatment with 50 mg·kg−1·day−1 for 14 weeks.
The drug, which ameliorates impotence by increasing blood flow to the penis, is also available now under other trade names.
Fenofibrate has been found to ameliorate vascular function, improving blood flow in diabetics [ 49].
We suggest that higher superfusion flow rate could ameliorate this problem.
These results demonstrated nicorandil ameliorate endothelial dysfunction, without changing flow velocity or vascular smooth muscle function, in STZ rats.
