By influencing two fundamental biochemical characteristics of the aged phenotype, energy metabolism and proteostasis, this intriguing dipeptide has the potential to ameliorate a range of age-related conditions.
TNFα inhibition has been shown to ameliorate a range of inflammatory autoimmune diseases, but rarely has been associated with the development of MCD and other glomerular diseases [ 2– 4].
However, the amplification of pollution effects on asthma via psychosocial stress suggests that interventions aiming to eliminate discrimination might have benefits for ameliorating a wider range of health problems than initially supposed (i.e. not just mental health).
Animal studies demonstrate that cell-based therapy involving direct injection of Treg cells ameliorates a wide range of experimental models of inflammatory and autoimmune diseases [1] [3].
It is a complex sensorimotor rhythmic activity integrating multiple physical, cognitive and social elements, all of which have the potential to ameliorate a wide range of physiological and cognitive fall risk factors.
Transplantation with NSPCs have ameliorated the clinical features in a range of experimental models of neurological disease, including stroke [4]; Parkinson's disease [5]; spinal cord trauma [6]; and multiple sclerosis [7], [8].
The IGF-1R pathway has received extensive attention as its inhibition increases lifespan and ameliorates neurodegenerative diseases in a range of model organisms (1– 4).
The results indicate that lubeluzole may be effective in ameliorating ionic or osmotic stress in a range of pathological conditions involving the rise of extracellular K+, and also in decreasing the vulnerability to stress in rats with hepatic failure.
The strengths of the Dunedin Study are its longevity, sample size, retention rate, detailed oral health data, and information on a range of potential risk, ameliorating, exacerbating and confounding factors.
Separate investigators have independently demonstrated the ability of antioxidant compounds to ameliorate the toxicity of 5-FU and a range of other chemotherapeutic compounds, including oxaliplatin and paclitaxel (Alexandre et al, 2006b).
