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The incidence of AA amyloidosis in TRAPS and CAPS is approximately 25% but is less than 5% in HIDS, perhaps because the disease often ameliorates spontaneously in early adulthood.
Furthermore, EH-201 (THSG) improved blood flow and ameliorated vascular senescence in spontaneously hypertensive rats (SHRs) (Han et al., 2012), without affecting blood pressure and body weight, after treatment with 50 mg·kg−1·day−1 for 14 weeks.
Given the minimal PD activity of synovial inflammation in patient 10, who carries the same NOD2 mutation as patient 2 but has never received treatment, we also speculate that active synovial inflammation can spontaneously ameliorate, at least in some patients with Blau syndrome, at some point after their adolescence.
Sitagliptin protected the endothelial function of the renal artery in spontaneously hypertensive rats, and exenatide ameliorated the endothelial dysfunction in the renal arteries from hypertensive patients in an ex vivo study [ 26].
The antioxidant enzyme-oriented treatment includes also genetic therapy which was proved efficient for genetic transfer of EC-SOD, which ameliorated endothelium function and decreased the arterial pressure in spontaneously hypertensive rats (Chu et al. 2003).
In addition, the colitis and colitis-associated colorectal tumors (CAC) spontaneously generated in IL10−/− mice can be ameliorated if mice are kept in germ-free conditions [26] or concurrently ablated of TLR4 [27].
Could it have been ameliorated?
All these can be ameliorated by insurance.
(They have been ameliorated: made better).
First, how would job losses be ameliorated?
This situation could have been ameliorated, if not avoided altogether.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com