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Pretraining administration of levetiracetam ameliorated memory impairments of aged C57BL/6 mice (17 20 months of age) in the contextual fear conditioning paradigm.
We previously demonstrated that the injection of S14G-HN, a highly potent HN derivative, into brain ameliorated memory loss in an Abeta-injection mouse model.
A related study attempted to examine the restorative effect of VEGF for AD in vivo[ 69] and found that intraperitoneal injection of VEGF in an AD mouse model ameliorated memory impairment in these mice compared with non-transgenic controls.
Overexpression of CBP/KAT3A ameliorated memory impairment in this model (Caccamo et al, 2010).
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In preclinical studies, choline partially ameliorates memory and learning deficits from prenatal alcohol exposure.
The present study was designed to determine the hypothesis that administration of 17-AAG could attenuate cerebral infarction and improve neuronal survival, thereby ameliorating memory impairment in a rat model of GCI.
During the test trial, Aβ25 35-injected mice hAβ25 35-injectedly lower latency timicehad control mice, but this wasignificantlylowerng the dailatencynistimeion of B. breve A1 or donepezil (Fig. 1g), indicathan that B. breve A1 controlmiceorate memory dysfunction in mice administered Aβ.
Therefore, more speculatively, it might even imply a potential target to ameliorate memory decline due to age-related brain atrophy.
For example, rolipram, the most widely used PDE4 inhibitor, ameliorates memory impairments in APP-PSEN1 double transgenic mice [56].
DCP-LA ameliorates memory deficits in rat models treated with amyloid-β peptide or scopolamine [ 32].
Prevention of hippocampal neuronal deaths provides a potential new therapeutic strategy to ameliorate memory and cognitive impairment of many neurological disorders.
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CEO of Professional Science Editing for Scientists @ prosciediting.com