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Noise may be ameliorated in a number of ways.
The ventricular dysfunction is ameliorated in a strain with a knock-out of HIF-1α, further implicating HIF in the dysfunction.
The introduction of a neutralizing anti-PDGF antibody has shown that both mesangial proliferation and glomerulosclerosis can be markedly ameliorated in a rat glomerulonephritis model [14].
A subsequent study using the sirtuin inhibitor nicotinamide found that tau phosphorylation is ameliorated in a triple transgenic model of AD.
The GI damage caused by NSAIDs can be ameliorated in a number of ways - most effectively by stopping the drug (often an impractical solution), by selecting a less toxic NSAID or by adding a second drug, either prophylactically or following a complication [ 2].
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In laminin α4-deficient mice, compensatory expression of laminin α5 is found in the endothelial cell basement membranes of the CNS and in these mice, EAE progression was ameliorated in association with a reduction of cellular infiltrates [ 85].
The silica-induced exacerbation of lupus pathology in NZM mice was ameliorated in mice coinstilled with rottlerin, a putative PKC-δ inhibitor (Brown et al. 2005).
Furthermore, unexpectedly, BiPN was significantly ameliorated in some patients who received a salvage treatment with lenalidomide, and this improvement may also be attributable to the putative anti-inflammatory actions of lenalidomide as well as dexamethasone.
Meanwhile, dyslipidemia were ameliorated in both models.
In this study, we showed that the abrogation of CCR9 ameliorated arthritis in a murine model of RA.
Furthermore, even in the less well epigenetically defined case of fibromyalgia, mS-11 ameliorated symptoms in a mouse model, suggesting that fibromyalgia is related to the dysfunction of NRS F/REST
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