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10 As the major polyphenolic constituent in green tea, EGCG can delay the onset of T1DM in spontaneous non-obese mice with diabetes, reduce blood glucose levels and ameliorate the decrease of pancreatic islet mass in the streptozotocin-induced mice with diabetes, and attenuate high glucose-induced harmful effects in other animal and cell models.
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We found in this study that sulforaphane activated Nrf2, upregulated downstream HO1 and NQO1, suppressed TGVS activation, and ameliorated the decrease of tactile thresholds in NTG-induced rats.
The protein expression of CD2AP was decreased in vehicle KK-Ay mice, and treatment with Qiwei granules ameliorated the decrease.
Linagliptin administration ameliorated the decrease in cerebral volume and neuronal cell number in hippocampus and cortex of diabetic mice.
JTE-052 ameliorated the decrease in PWT in a dose-dependent manner (Fig. 3), but the efficacy was not complete.
JTE-052 ameliorated the decrease in the maximum angle on day 22 in a dose-dependent manner (Fig. 4a).
Reddy, et al showed that treatment with ciglitazone (an agonist of PPARγ) for 8 weeks ameliorated the decrease in elastin contents [ 16].
We also observed that noise exposure attenuated mitochondrial complex IV activity, whereas MB pretreatment ameliorated the decrease of complex IV activity induced by noise exposure in vivo.
OPG administration by inhibiting osteoclast activity ameliorates the decrease in both bone mineral density and bone strength in immobilized rats [ 29].
Linagliptin administration ameliorated the decrease in volume of hippocampus (P < 0.05) or volume of cortex (P < 0.05) of BCCAO-subjected db/db mice.
Treatment with GAGs ameliorated the decrease in body weight; the greatest effect was achieved after treatment with both polymers (Fig. 2B).
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