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We address therapeutic approaches based on the principles of synthetic immunology that either ameliorate disorders of the immune system by interfering with the immune response, or improve diverse pathogenic conditions by exploiting immune cell effector functions.
The possibility of one day harnessing macrophage plasticity to treat or ameliorate disorders including obesity, cancer, organ damage, intestinal disorders, neurodegeneration, and cardiovascular disease in which these cells play a role, is a very exciting prospect.
Taken together, we suggest that live animal HCS for compounds that ameliorate disorders of proteostasis is feasible [6].
Hence, the phytococktail could be used as natural source of antioxidants to ameliorate disorders associated with oxidative stress.
Our findings confirm TPCs as integral components of endogenous NAADP receptors, demonstrate that TPCs are both functionally and spatially diverse endolysosomal channels, and show that perturbation of TPC function and NAADP signaling might both underlie, and be used to ameliorate, disorders of endolysosomal trafficking.
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A better understanding of these pathophysiological events may provide a potential pathway for designing novel therapeutics to ameliorate neurodegenerative disorders.
Using these organizational levels as a scaffold, we then discuss strategies that are currently used to ameliorate these disorders, and forecast future interventions that hold therapeutic promise.
In line with previous report, the current study also supports the potential of JNK inhibition as a possible therapeutic strategy to ameliorate neurodegenerative disorders associated with oxidative stress and cognitive impairment.
has been demonstrated to possess multiple biological activities and abilities to ameliorate metabolic disorders [ 5].
In animal models, IL-4 is the most successful means by which to ameliorate autoimmune disorders that are caused by activated Th1 cells.
These genes can be further investigated and may become potential targets for therapeutic approaches to ameliorate neurological disorders characterized by BBB disruption.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com