The downstream N/C ratio was marginally greater than 0, and this also suggests ample ambient N availability (Table 4).
Taken together, HapX acts as a Janus-type transcription factor mediating both repression and activation of cccA and consequently vacuolar iron storage depending on the ambient iron availability.
Collectively, our study uncovers a novel regulatory mechanism mediating both iron resistance and adaptation to iron starvation by the same transcription factor complex with activating and repressing functions depending on ambient iron availability.
Collectively, our study uncovered a novel regulatory mechanism in A. fumigatus and other filamentous fungi mediating both iron resistance and adaptation to iron starvation by the same transcription factor complex, comprising the CBC and a HapX homodimer, with activating and repressing functions depending on ambient iron availability.
Here, we provide an explanation for this synthetic lethality by demonstrating that HapX mediates both repression of vacuolar iron storage during iron starvation and activation of vacuolar iron storage during iron excess, i.e. HapX displays inverse activities depending on the ambient iron availability.
Given its abundant availability, ambient thermal energy harvesting has the potential to power standalone microelectronic systems.
These systems mediate responses to a wide range of environmental conditions such as nutrient availability, ambient temperature, or external osmolarity.
The off-label use of misoprostol, a prostaglandin E1 analogue, has entered into clinical practice for this indication because of its strong uterotonic properties, and its ease in oral administration, stability at ambient temperatures, wide availability, and low cost.
In recent years, however, it has become evident that the ecological outcomes of plant-mycorrhizal fungus interactions are highly variable, ranging from mutualism to parasitism depending on a variety of biotic and abiotic environmental factors, especially ambient soil nutrient availability [ 16, 17].
Also, the efficiency of a PV system is influenced considerably by a number of climatic variables, such as solar irradiance availability and ambient temperature.
