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The phrase "always difficult to isolate" is correct and usable in written English.
You can use it when discussing concepts, variables, or factors that are challenging to separate or identify in a particular context.
Example: "In scientific research, it is always difficult to isolate the effects of one variable from another."
Alternatives: "consistently hard to separate" or "frequently challenging to distinguish".
Exact(1)
The causes for major market moves are always difficult to isolate.
Similar(59)
It's difficult to isolate specific factors and it's impossible to account for every possible factor, so there's always going to be some fuzziness in the results.
Insulin, however, proved difficult to isolate.
"It is very difficult to isolate a couple of provisions," Mr. Daschle said.
Such systems, however, can be difficult to isolate and to access via microscopy.
LNSCs are extremely rare and difficult to isolate, hampering the thorough study of their biology.
This makes it difficult to isolate the effect of trade reforms per se.
It's difficult to isolate specific reasons for increased or decreased turnout.
Big companies operating in many markets may find it difficult to isolate a single "typical" offering.
Microorganisms, by definition, are tiny, and as such are difficult to isolate, grow and study.
It also could be difficult to isolate from the solvent.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com