Exact(2)
However, the effect of exogenous surfactant has not been studied directly on alveolar type II cells (ATII cells), a key cell type responsible for alveolar function and repair.
In type 1 diabetic patients who maintained near-normoglycemia, these parameters are near normal, suggesting a relationship between alveolar function and systemic microangiopathy.
Similar(58)
In one study, restoration of glutathione through its precursor N-acetylcysteine into the alveolar environment improved alveolar phagocytic function and decreased alveolar damage in animal models (Yeligar et al. 2014).
Additionally, lung pathology is characterized by loss of alveolar barrier function and alveolar edema fluid accumulation [9].
24 Similar findings have been reported in the alveolar function of guinea pigs exposed to ethanol in utero resulting in low macrophage GSH.
In an animal model, IUGR induced in late gestation produced alterations in alveolar function, corresponding to rapid development of alveoli during this time period (Maritz et al. 2001).
Although the underlying pathogenetic mechanisms are not fully understood, exposure to common gaseous pollutants affects the susceptibility to and the progression of infectious diseases through the impairment of local bronchial immunity, the modification of alveolar macrophages function and the epithelium damage [11].
Consequently, alveolar macrophage function and cytokine production is impaired, which may enhance susceptibility to infectious diseases (6 ).
A protective role of adiponectin on mice lung through inhibition of alveolar macrophage function and vascular homeostasis regulation has been found by Summer et al. [ 115].
Further, the currently used model of VILI meets the ATS criteria on lung injury in animals, including the evidence of inflammation, microscopic tissue injury, alteration of alveolar barrier function, and impaired oxygenation [ 25].
41 The safety profile was consistent with a previous phase 1 study of mavrilimumab in subjects with RA. 13 Due to the link between GM-CSF and alveolar macrophage function and clearance of lung surfactant proteins, we carried out intensive pulmonary lung function tests as well as assays for biomarkers of lung damage such as SP-D and KL-6.
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