The phrase "altogether different with" is not correct in standard written English.
It is typically used to express a significant difference in a comparative context, but the preposition "with" is not appropriate here.
Example: "The results of the experiment were altogether different from what we expected."
Alternatives: "completely different from" or "entirely distinct from".
In food waste, the situation is altogether different, with 40% still ending up in landfill.
Traditionally, especially in the UK, MBAs are undertaken after several years of work experience, which neatly ties in with the time when many women are considering doing something altogether different with their lives.
With my little experiment, I'd intended to prove that I could fill my calendar with meetup after meetup, but with it came an altogether different result: With each outing, I grew more confident; I could fly solo and have a great time doing it.
The show has been rewritten and updated, with three new songs, and given an altogether different production (with only the authors and one of the actors still at the turnstile).
It's an altogether different tale with banned substances.
(Chilean pisco is an altogether different product, with different ingredients and processes that yield a different flavor).
I have even stood in a gallery that posed as an altogether different gallery, with a fake name, a fake director and fake art on the walls.
It's a simple project in concept: Horn at different moments of life, from a teen-ager with seventies hippie hair to an adult with the gentlemanly look that she sports now, but the images are so radically different that they might be representations of altogether different women with different lives.
Only when I got to the third story, which heads off in an altogether different direction with a new set of characters, did I realize: oh, she isn't.
And the company went in an altogether different direction last year with Blocks — a system of square music pads with playable light-up scales that can be arranged in any number of configurations.
They can be altogether different when connected with human beings -- real or fictional.
