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"altogether different from" is correct and usable in written English.
You can use it when you want to indicate that one thing or situation is completely or very distinct from another. Example: His leadership style was altogether different from that of his predecessor.
Exact(60)
It was altogether different from communicating.
Weiss's detection method was altogether different from Weber's.
Altogether different from either Rossini or Donizetti was Bellini.
This case is altogether different from Darwin v. Connecticut, 391 U.S. 346, 350, 88 S.Ct.
The tone of the Oxfordshire serious case review is altogether different from the government's.
In truth, I was to learn something from her altogether different from what I had expected.
"In some respects, it may not be altogether different from hiring a consultant".
Such views make for a Cathar history altogether different from Sumption's or Le Roy Ladurie's.
It was quite an achievement, though altogether different from that of "Gatz".
This made them altogether different from the parallel ridges to the north.
But that is altogether different from Europe's approach of picking the firms that pick the winners.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com