The phrase "altogether a large" is correct and usable in written English.
It can be used when describing the totality or overall size of something, often in a quantitative context.
Example: "The project required altogether a large amount of resources to complete successfully."
Alternatives: "overall a significant" or "in total a considerable".
His Hearst is altogether a larger, more sympathetic figure than the vindictive, humorless crypto-fascist seen by the left.
Within a couple of hours, Timor decides that even this precaution is insufficient and bans use of the bathroom altogether, placing a large plastic bucket in the stairwell to serve as a communal urinal.
The scarcity of flexible work eventually forces many women out of the workforce altogether, leaving a large segment of qualified, ambitious professionals untapped.
"He was such a huge Formby fan he owned seven ukuleles altogether and accumulated a large archive of Formby memorabilia". Some of the other items from Mr Johnson's collection, including Formby bow ties and an original script for 1942 Formby film Much Too Shy, were also sold.
Altogether, Diocletian effected a large increase in the number of bureaucrats at the government's command; Lactantius was to claim that there were now more men using tax money than there were paying it.
And it clearly means something altogether more sinister to a large segment of our population.
Altogether these data suggest a large degree of similarity between DRBP76 mRNA targets in HEK293 and HTB-14 cells, in line with similar DRBP76 isoform expression in these transformed cell lines.
Moreover, a typical miRNA regulates hundreds of target genes [ 38- 41] and altogether they could target a large proportion of genes up to 30% of the genome [ 42].
While biocontrol organisms present the potential to study a wide range of Allee effects, they also provide the opportunity to study invasions free from Allee effects altogether, as parasitoid wasps, a large group of biocontrol organisms, are unlikely to experience any density-dependent dynamics at low densities (Fauvergue et al. 2007; but see Fauvergue and Hopper 2009).
Altogether, the impact of such a large convict population was less grim and ugly than might be expected.
To compensate for the small number of suitable subjects, we collected fMRI data during a large number (altogether 585) of AVHs.
