Although this orientation-dependent activation hypothesis for single transmembrane receptors was initially debated because of the suggestion that other properties of this EPO mimetic could result in loss of activity [ 40], subsequent studies supported that activation of single transmembrane receptors might be beyond a ligand-induced encounter of the cytoplasmic domains.
This orientation is rather counterintuitive, although an efficient intramolecular network of hydrogen bonds among the three D-ring OH groups might be masking their polarity more effectively than the lone 17β-OH in E2.
Among the noted crystal packing interactions, the N-terminal TEV site remained uncleaved and participated in packing against a symmetry-related molecule in both structures, although the orientation of this segment was different in the absence and presence of RAB.
Most MWNTs were well oriented along the fiber axes, although the orientation of the CNTs was known to be difficult to achieve by conventional mechanical drawing.
After 50 ns of MD simulation, the positions of HMAs did not change significantly, although the orientation became more defined (Fig. 2A C).
Although the orientation of pars defects varies widely [7, 9], in most cases they lie closer to the coronal plane in the pars interarticularis [4].
Although the orientation of WALP19 varies slightly in the different lipids, hydrophobic mismatch does not seem to be the dominant factor causing the tilt.
Although the orientation maps exhibited an anisotropic dislocation boundary structure it was shown that the mean disorientation angle between point pairs saturated and became isotropic if their spacing was large enough (typically >30 μm).
This 'end on' attachment is reminiscent of the anchorage of FG repeat domains to the NPC channel walls, although the orientation is upside down.
Although the orientation of the MTSL chain remains unknown the result is striking as residue 54 is further remote in the sequence from 90 than residue 64.
We use the same notation for codirectional sequences both in the normal and in the complementary strand, although the orientation of the two genes is opposite in the two cases.
