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Although this checkpoint formally monitors chromosome attachment to the spindle, there are at least two components addressed here that potentially impact the SAC, centrosome anchorage and nuclear occupancy.
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Although the core components of this checkpoint mechanism have been identified, two main questions remain open: How can a loaded granule activate PKD and what confers specificity of this mechanism to insulin granule formation in β cells?
"This checkpoint, we are living here calmly.
"This checkpoint is closed because of the recent attacks.
This checkpoint, he said, had to be destroyed.
At this checkpoint anyway.
Together, these results suggest that E-caddCR4h overrides this checkpoint.
Although the precise mechanism linking cell size to S phase initiation remains unclear, Cln3 is activated at this checkpoint.
Interestingly, Stn1 overproduction inactivates the S phase checkpoint in budding yeast, and, although the biochemical mechanism explaining this interaction is not known, it is tempting to speculate that some aspect of this checkpoint inhibition function is critical for Stn1 function (Gasparyan et al., 2009).
This checkpoint mechanism is conserved from Yeast to Human.
This checkpoint activation is known to facilitate DNA repair.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com