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Discover LudwigThe phrase "although there were substantial differences in" is correct and usable in written English.
You can use it to introduce a contrast or exception when discussing varying aspects or characteristics in a particular context.
Example: "Although there were substantial differences in their approaches, both teams managed to achieve their goals."
Alternatives: "despite significant variations in" or "even though there were considerable discrepancies in".
Exact(3)
All these semaphorins were relatively efficiently expressed in MDA-MB-231 cells although there were substantial differences in the expression levels obtained with different semaphorins (Fig. 2A).
Ironically, there was strong support for metric invariance, although there were substantial differences in the construct reliabilities for some of the measures.
Our results are consistent with the GAMI study by investigators in Sweden, 13 although there were substantial differences in study populations and backgrounds.
Similar(57)
Although there are substantial differences in the computational cost, however, with the current solutions of Big Data and Edge Computing, the required complexity is not an issue.
The three genomes of C. subterraneus showed high similarity, although there are substantial differences in their gene composition and organization.
Although there are substantial differences in the design, density, and replicate structure of the probes, the comparison indicates a generally high level of concordance between platforms.
Although there are substantial differences in the design, density, and number of replicate probes, the comparison indicates a generally high level of concordance between platforms, despite differences in the reproducibility, noise, and sensitivity.
However, one can imagine there being substantial differences in concentration.
There were substantial differences in accuracy between observers from different regions.
Although absolute differences in median wait times between LHINs were modest, there were substantial differences in the proportion of patients who were treated within RMWT.
There were substantial differences in the growth kinetics upon methodology, although general trend seemed to be the same.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com