The phrase "although there were significant changes in" is correct and usable in written English.
It can be used to introduce a contrast or exception regarding changes that have occurred in a particular context or subject.
Example: "Although there were significant changes in the company's structure, the core values remained the same."
Alternatives: "despite the notable changes in" or "even though there were major alterations in".
Although there were significant changes in joint biomarkers after IA HA treatments, the results of long-term treatment remain unclear.
Although there were significant changes in the levels of many of the mRNAs recruited to Ago2/RISC in the presence of specific miRNAs, there were also many associated mRNAs that were only slightly altered in expression level.
Although there were significant changes in cancer incidence noted between 2000 and 2010, there was significant heterogeneity in these trends based on tumor site, histology, and demographic factors.
Thus, although there were significant changes in self-efficacy scores for those completing the intervention program and not in those completing the control program, there was no difference between groups as allocated, especially when adjusted for covariates.
We show here that loss of spastin in patient-derived ONS cells had no effect on cell proliferation or on eight other 'metabolic' functions, although there were significant changes in microtubules and microtubule-associated functions (Table 3).
Although there were significant changes in HFS, PAID, and ADDQoL scores from baseline to 16 weeks within study arms, there were no differences when comparing the changes in the three study arms.
On the {110} face, the hardness results again show little variation with orientation, although there are significant changes in the ERSS values.
Mollusc species richness was remarkably similar across seasons, although, as with other taxa, there were significant changes in community structure.
There are significant changes in the city's northern suburbs.
There are significant changes in the magnitude of the stresses.
Although for several of the drugs individually there were significant changes from baseline, overall there were no significant differences between the different agents.
