The phrase "although there is major" is correct and usable in written English.
It can be used to introduce a contrast or exception regarding a significant issue or factor.
Example: "Although there is major concern about climate change, many people still refuse to take action."
Alternatives: "despite the significant" or "even though there is considerable".
For the most part, that turned out to be a wise decision, although there were major problems.
Exploration of such fields outside the United States and Canada is barely in its infancy, although there are major shale fields across Europe, China, Australia, Africa and South America.
One-dimensional 'lanthanide-phosphate' chains are a key feature in both structures, although there are major structural differences between the chains, with (I) displaying octahedral GdO6 coordination and (II) showing eight-coordinate NdO8 polyhedra.
Prior, who remains England's Test vice-captain although there are major doubts over his future after he was dropped in Australia once the Ashes were lost, became the first witness to England's painful unravelling this winter to break his silence – inevitably on Twitter – after being smoked out by Pietersen's most voluble cheerleader, Piers Morgan.
Although there were major differences in the volatile constituents identified, this was not surprising due to the very different experimental conditions of this study.
It was termed as "cold" because there was no large-scale fighting directly between the two sides, although there were major regional wars in Korea, Vietnam and Afghanistan that the two sides supported.
Although there are major differences between mammalian and insect immune systems, pathogenic fungi often require the same traits for virulence in mammalian and non-vertebrate hosts [24].
Although there are major differences between above and belowground systems, it has been proposed that some of the mechanisms underlying patterns of species richness aboveground may also be important belowground [9].
These figures are in good agreement with sequencing data of 60 PLMVd-sRNAs from infected field trees [26], although there are major differences in the methodologies and inferences between both studies (see below).
Although there are major alterations in fatty acid metabolism in pept-1 lg601 pept-1 lg601d long-chain FA and PUFA but increased MUFA levels, this does not explain the high fat accumulation in this with streduced
