Although all of the sensitive lines had normal p53 as expected, the majority of the cell lines with normal p53 were insensitive to these drugs.
It was the first time in his managerial career, according to McCarthy, that his chairman had entered the dressing room to deliver such a rebuke and, although the manager approached the sensitive subject with caution, there was little doubt a line had been crossed.
Although buoyed up by the sensitive support of his wife and family, as he later confessed, "I often felt that I would be better dead".
Although the more sensitive among us might have simply been scarred for life by the heat, others who have ventured deep into that hot terrain tell tales of a much mellower after effect, a uniquely pleasurable calm.
Although the most sensitive and specific method seemed to be APACHE II scoring, it is time consuming and complex.
These data show that the expression of the same gene-set was also modified in a second type of neurocyte, although the most sensitive model for detecting the effect of Gelsemium s. is the SH-SY5Y cell line.
Both measures seem to perform well using un-weighted, rather than weighted, scores, although the individually sensitive weighting system of the OIDP inventory gives prominence and increased validity to respondent views [ 11, 12].
The LODs are often below 1 µg/L, although the most sensitive methods reached LODs of ≤0.2 µg/L (Maestri et al., 2005; Melikian et al., 1999b; Paci et al., 2007).
