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The phrase "although substantial progress has" is correct and usable in written English.
It can be used to introduce a contrast or exception in a statement, often followed by a clause that presents a different perspective or outcome.
Example: "Although substantial progress has been made in renewable energy technologies, there are still significant challenges to overcome."
Alternatives: "even though significant advancements have" or "despite considerable progress having".
Exact(26)
Although substantial progress has been made, breeding and genetic modulation of rice plants in order to improve abiotic stress tolerance is still a challenge.
Although substantial progress has been made in exploring the structural neuroanatomy of mood disorders, the field would benefit from large-scale studies with prospective, longitudinal designs.
Although substantial progress has been made in optimizing the adjuvant treatment of breast cancer, many of the most important proven agents carry a risk for potentially severe toxicity.
Although substantial progress has been made in developing Plk1 PBD inhibitors during the last several years, these inhibitors suffer greatly from low binding affinity, poor specificity, or low membrane permeability.
Although substantial progress has been made toward genome-wide annotation of mammalian enhancers, their temporal activity patterns and global contributions in the context of developmental in vivo processes remain poorly explored.
Although substantial progress has been made in the development of methods able to identify the species formed during self-assembly and to describe the kinetic mechanisms of aggregation, the structure(s) of non-native species, including potentially toxic oligomers, remain elusive.
Similar(34)
Although a substantial progress has been made to unravel the molecular function of OPA1, the pathogenesis of DOA remains poorly understood.
No substantial progress has been made.
I'm pleased to say that substantial progress has been made.
In the past few years substantial progress has been made in this area.
Substantial progress has been made in this direction.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com