Although the molecular mechanisms are still not understood, it's known that the gallium causes gaps in the oxide layer that allow the aluminum to react quickly with the oxygen in water, but not with the oxygen in air.
The exact mechanisms are still not understood, although several have been proposed.
The molecular mechanisms permitting mitochondrial tubulation are still not understood although they are under active investigation [ 16, 17].
Endo-siRNAs are involved in gene regulation and transposon silencing, although the latter mechanism is still not understood.
The source of this trend is still not understood although some factors that may influence it have been discussed already (6).
The mechanisms of islet amyloid formation in type 2 diabetes are still not understood, although impairment of the prohormone processing machinery has been thought to play an important role in the initiation and progression of this process.
Importantly, the activation of the sporulation-specific promoter of ftsZ is still not understood, although it is known that overexpression of ftsZ can partially suppress the phenotypes of all the whi mutants (Willemse et al., 2012) and that BldD represses the sporulation-specific promoter of ftsZ (den Hengst et al., 2010).
Although the precise pathogenic mechanism is still not understood, prion diseases involve the deposition of aggregates of disease-related isoforms (PrPSc) of a host-encoded protein (PrPC) in the central nervous system.
Although the action of Tsix is still not understood, Tsix transcription and chromatin modifications in the Xist promoter (possibly mediated by Tsix) provide a threshold that has to be overcome by the XCI-activator, allowing accumulation of sufficient Xist molecules to silence Tsix and spread in cis.
Although the role of soluble ectopeptidases is still not understood, NEP-like proteins have been hypothesized to modulate the host immune system by degrading immune-specific peptides [ 48].
Although much of the underlying pathophysiology is still not understood, the major pathologic pathway envisioned in the Sentinel Acute Pancreatitis Event (SAPE) model appears to be the best way of understanding how many patients with AP and RAP progress to CP. Identifying the underlying genetic factors that lead people who develop AP to become susceptible to CP, silently or through RAP, is needed.
