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Although simplification strategies make the raw expression profiles coarse-grained, which could somewhat ameliorate the noise in the data, inevitably the simplification leads to loss of information, which may exacerbate the situation of limited sampling.
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Although such simplification may introduce some bias into the estimated afterslip distributions, they can be still considered to preserve the essential feature of them.
Although stepwise simplification approaches have been criticized [53], there is no perfect approach to choosing among multiple predictor variables in the absence of prior models [54].
Although this simplification may impose a bias on the estimated adjustment, we consider this bias to be minor.
Response: The assumption of constant levels of A, B and C on the tissue boundary, although a simplification is, we believe, reasonable for the following reasons.
Although this simplification compromises detail in terms of the ecology behind wolf dynamics, it may facilitate further manipulations while, at some level, incorporating trophic interactions between wolves and moose (see, e.g. [ 13, 18]).
Although this simplification may affect the level of RMI, it might not impact the results of decompositions of black/white differences in RMI, since estimates for both blacks and whites would similarly be affected by period-cohort inconsistencies.
Although some simplifications were adopted, the successful completion of this trial will inform future designs of both national and institutional trials and would allow immediate clinical adoption of SBRT trials for oligometastases.
Although the simplifications came at the cost of the optimality still high gains in comparison to a simple load-balancing algorithm were obtained and close to optimum performance could be shown by simulations based on a duality bound.
This simplification, although technically true, glosses over some details (e.g., evolution is allele frequency change in a population over time) that allow misconceptions to persist unexamined.
Although thisis a simplification, it allows us to better focus on the user dimension and tocluster users with respect to the perception they get from the interaction with thesystem (i.e., attention in exchange for activity).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com