Although QT prolongation is associated with an increased risk of torsades de pointes (TdP), it is unclear how clinicians determine risk in individual patients with prolonged QT.
While these derivatives are commonly used [34], they do not prevent the progression of the pathology [7] and although the prolongation of pregnancy is better with DHPs, as compared to hydralazine and labetalol, the occurrence of delivery is still premature [35].
Although significant prolongation of PFS may be achieved in selected patients, recurrence after CRS and IPC is common.
Although QTc prolongation was grade 1 or 2, our protocol required discontinuation of two patients due to this.
Although, the prolongation of survival after adjuvant therapy did not reach statistic significance the EORTC trial confirmed that the survival of patients without adjuvant therapy is poor (10 12 months).
Although QT prolongation was observed with high dose droperidol in this study, there was little evidence to support droperidol being the cause and QT prolongation was more likely to be due to pre-existing conditions or other drugs.
Although QT prolongation has been discussed prominently in ziprasidone, a single dose of ziprasidone to treat TS was well tolerated without clinically significant effects on electrocardiograms collected around the time of maximum serum concentration [ 213] and even in higher doses no elevated risk of QT prolongation has been reported compared to other antipsychotics [ 266].
Current evidence indicates that new targeted treatments, notably monoclonal antibodies such as ramucirumab and necitumumab, and immunotherapies such as nivolumab and pembrolizumab can provide survival prolongation, although the benefits are still relatively modest.
Although QT interval prolongation in TCM carries a risk for arrhythmias in the acute and sub-acute period, sudden cardiac death and life-threatening ventricular arrhythmias are uncommon [1, 3].
The contrary is the case, 10 μmol/L ranolazine in addition to d-sotalol sufficiently suppressed the occurrence of TdP in our model although further APD prolongation was present.
